Research & Career

Some Big Questions:

Electronic Structure and Symmetry:

I want to study the principles behind the interactions between metals and proteins. I believe symmetry plays a role in the seemingly asymmetric coordination sites. I have a simple theory that describes this phenomenon. I have yet to equip myself with mathematical tools to consolidate these ideas into a theory. How useful will that be? I have no idea.

Thanks to my work involved in the recent publication: Morales, et. al. (2013), I started to appreciate the electronic structures that govern the protein-metal interactions. The first step is set.

Protein Dynamic Structures:

I am naturally drawn to the study of protein structures where crystallography fails to predict their behaviors. The the hidden electronic structures in proteins might be the next barrier in our understanding of the structural-functional relationship in them. How could we approach these questions from a theoretical point of view is a real challenge.

The Mathematics of Interactions:

With all the theories of molecular bonding. Is there any better way to understand bonding interactions in chemical systems such as hydrogen bonding, or polar-polar interactions? From a theoretical point of view, is it not interesting to think about what is special about bonding between molecules?



Morales, KA, Yang, Y, Long, Z, Li, P, Taylor, AB, Hart, PJ, Igumenova, TI (2013) Cd2+ as a Ca2+ surrogate in protein-membrane interactions: isostructural but not isofunctional. J. Am. Chem. Soc. 135: 12980-3.


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